Affiliations

The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Logical details

Imply SBP prior to urinary sodium in order to potassium (Na + /K + ) removal proportion at the time of examination along with weight loss input from Weight loss Remedies for Stop Blood circulation pressure (DASH) high sodium (HS) and you will lowest sodium (LS) diet within the (a) sodium sensitive (n = 71), (b) salt resistant (letter = 119) wapa someone, values found due to the fact indicate ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

Then, multiple research has recommended that blood pressure protection evoked from the K + consumption tends to be dependent on weight-loss Na + intake [twenty-eight, 29]. In our investigation of your Dashboard-Sodium dataset i noticed no association having urinary K + removal and you will SBP, within the patient tests check out otherwise throughout Dash fat loss input when Na + consumption was modified, suggesting a liberty of one’s results of Na + and you can K + into SBP within studies. This new 2019 DRI Declaration figured there clearly was diminished evidence towards the consequences from K + to the blood pressure levels and you will did not introduce a DRI out of K + . The research contain the 2019 DRI Report and you can implies that weight loss K + supplements might not notably dump hypertension throughout the standard society.

Conclusion

Stamler J, Flower Grams, Stamler R, Elliott P, Dyer An effective, Marmot Meters. INTERSALT analysis findings. Public health and healthcare ramifications. Blood circulation pressure. 1989;–seven.